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Gel Permeation/Size Exclusion Chromatography (GPC/SEC)

GPC/SEC is a size separations technique employed to separate complex mixtures of macromolecules according to their hydrodynamic size. If the chemistry of the sample(s) is known, then
appropriate set up conditions such as solvent, solvent additives, experimental temperature, and column setup can be suggested.

This technique provides a wealth of information about synthetic polymers, biopolymers, oligomers, and small molecules including:
  • Molecular weights (Mn, Mw, Mz, Mp)
  • Molecular weight distribution (PDI)
  • Concentration
  • Cumulative Weight Fractionation
  • % Below or Above Target Molecular weight
  • Intrinsic viscosity (IV, [?])
  • Polymer chain conformation in solution
  • Copolymer, Conjugate, and Polymer Blend Composition
  • Radius of Gyration (Rg)
  • Branching Analysis
  • Hydrodynamic radius (Rh)
  • Aggregates Detections
  • Stability and Degradation
  • Trace Polymer Analysis
  • Failure Analysis
  • Xylene Solubles for Polypropylene and Ethylene Propylene Rubber
According to the application and true needs of customers, we employ various GPC instrument setups, configurations and detectors to obtain molecular parameters:
Conventional GPC/SEC
  • Detector configuration: RI or UV
  • Calibration curve of polymer standards of known molecular weight
Universal GPC/SEC-Viscometry
  • Detector configuration: UV or RI, Viscometry
  • Calibration curve of polymer standards of known molecular weight and intrinsic viscosit
  • Detector configuration: UV or RI, and Multi-Angle Light Scattering
Triple Detection GPC/SEC
  • Detector configuration: UV or RI, Multi-Angle Light Scattering, and Viscometry
Tetra Detection GPC/SEC
  • Detector configuration: UV, RI, Multi-Angle Light Scattering, and Viscometry

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GPC/SEC Method

GPC/SEC Method

GPC/SEC Training

PolyAnalytik’s team of highly qualified specialists offers a complete wealth of expertise in GPC/SEC hardware, software, applications, and columns from most vendors in the industry.

We offer on-site GPC/SEC trainings that cover several modules:
Introduction to GPC/SEC theory
  • Relative Molecular Weight measurement
  • Advance GPC/SEC detectors: Light Scattering and Viscometry
Method Development
  • How to pick the correct column
  • How to prepare samples for most reliable measuremen
  • How to pick the right solvent
  • How to design a complete reliable GPC/SEC method
Method Validation
  • How to design a complete GPC/SEC method validation Data Analysis
  • What is a good chromatogram?
  • How do I know my measurement is reliable?

On-site training is customized to your company’s needs and applications. Training length is 1-2 days. Please contact us for more information and pricing.

GPC/SEC Repairs and Validation Service

Since 2008, PolyAnalytik’s Field Service Specialists have helped GPC/SEC users in all
aspects of support.

We offer the following on-site services:
  • Troubleshooting and repairs
  • Preventative maintenance
  • Calibrations
  • Operational Qualification and equipment validation
  • Training