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polymer analysis
Capabilities
Size-Exclusion Chromatography (SEC)/Gel Permeation (GPC) is a technique that separates macromolecules (polymers) based on their hydrodynamic size in solution. The relative molecular weight (molar mass) of an unknown polymer can be determined by calibrating the GPC column set by injecting a series of narrow polymer standards, and subsequently comparing elution volumes. If the GPC system uses advanced detectors such as a light-scattering detector, calibration of the detector itself will provide the absolute measurement of molecular weight.
- Short review:
- Required state:
- Sample amount:
- Limit of detection:
- What it provides:
- Variations:
- Liquid chromatographic technique that separates macromolecules based on their size
- Solid or solution
- > 50mg
- 5 µg/mL
- Mn, Mw, Mz, Đ, Rg, RH, IV, branching, dn/dC, dA/dC, concentration
- GPC-MALS, preparatory/semi-prep SEC, high-temperature SEC
Liquid Chromatography Time of Flight tandem Mass Spectrometry (LC-MS), like conventional HPLC, separates molecules based on the affinity to the stationary phase of the column. Following separation in the LC column, the resolved sample enters the mass spectrometer which provides an accurate molar mass measurement for each molecule and/or fragment.
- Gel Permeation/Size Exclusion Chromatography (GPC/SEC)
- Dilute Solution Viscosity (DSV)
- Dynamic Light Scattering (DLS)
- Nuclear Magnetic Resonance (NMR) Spectroscopy
- Fourier Transform Infrared Spectroscopy (FTIR)
- Gas Chromatography (GC)
- Thermogravimetric Analysis (TGA)
- Differential Scanning Calorimetry (DSC)
- Powder X-Ray Diffraction (XRD)
Ideal pure sample amount: 100-500 mg. Please inquire if sample quantity is limited.
Fourier-Transform Infrared Spectroscopy (FT-IR) is a spectroscopic technique used to identify the presence or absence of certain functional groups on a material by measuring the resonance of covalent bond frequencies. These functional groups include carbonyl, hydroxyl, carboxyl, aliphatic, amine, amide, alkenes, and more.
Services Offered
- R&D projects
- ISO guidance documents and protocols
- Product development and registration
- Regulatory testing (in vivo and in vitro polymer degradations, aggregates detection)
- Pharmacopeia testing
- Manufacturing processes and operations (DSV, viscosity, MW, etc.)
- ASTM (American Society for Testing and Materials)
- QA/QC, Certificates of analysis, lot release testing (batch to batch various, stability, shelf-life)
we also do
GPC/SEC ANALYSIS
SPECTROSCOPIC ANALYSIS
THERMAL & PHYSICAL ANALYSIS
